Can the Measurements of Albumin and Glucose Be Correlated Each Other? A Physics-Based Theory

Abstract

As it is well known, the confirmation of albuminuria in diabetic patients requires of a test entirely different to blood-based tests. However, from the idea that the glucose dipoles can cancel the negative charges along the renal glomerulus, the measurement of glucose in blood might be strongly related to the exit of albumin through the Bowman space. In this paper, a theoretical treatment based at electrical interactions focused on bunches of glucose in the renal glomerulus is presented. The purpose of this theoretical work is toward the exact estimation of the relation between glucose and albumin that allows to measure in only one test both glucose and albumin. A few scenarios by using computational simulation are presented. The results suggest the importance of the geometry of flux of albumin and glucose in the theoretical assumptions.